Selective Androgen Receptor Modulators or SARMs are recognized as a new group of androgen receptor ligands. Androgens are considered as hormones which perform as ligands and they bind to the cellular androgen receptors. They are tangled in a complicated signal transduction path which results in a better expression of particular genes. Actually, if it is explained in simple terms then it can be said that androgens are hugely helpful in building muscle. A drug which can either stimulate or block those similar nuclear hormone receptors in various conditions is known as selective receptor modulator. They are meant to have similar impacts as androgenic drugs, such as anabolic steroids but they are more discerning in their actions.
The SARMs were formerly developed for people suffering from diseases, like anemia, chronic fatigue, osteoporosis, and muscle wasting. They were meant to be a better and improved substitute for TRT (testosterone replacement therapy). However, it is still to be noticed whether they really turn out to be superior substitutes or not. Bodybuilders buy SARMs online because they wish to increase the effectuality of steroid cycles minus aggravating health hazards or side effects. There are countless bodybuilders who believe in this fact that these are particularly helpful during their cutting cycles as these compounds aid in preserving lean mass without increasing water retention.
Types of SARMs and their functions
There are many kinds of SARMs available in the market and among them, some are stronger than the others and they contain a higher danger of side effects compared to the others. The popular compounds are:
- LGD-4033 (Ligandrol)
- GTx-024 or MK-2866 (Ostarine)
- GW-501516 (Cardarine)
- S-4 or GSX-007 (Andarine)
They have peculiar alphanumeric names and they haven’t been sanctioned for medical purposes. This is the reason the pharmaceutical marketers didn’t bother to name them yet. To understand the mechanism of their working system you are required to understand the physiology of hormones. By hormones are meant chemical messengers which your body utilizes for the communication of cells. When they reach the hormone receptors the commands get carried out.
By androgens are meant hormones which develop muscularity, like facial hair, deeper voice, lower levels of body fat etc. Testosterone is known as a popular androgen. Androgens apply their impact in your body in three chief ways:
- By binding to the androgen receptors of the cells.
- Transforming to the hormone, dihydrotestosterone which binds to the androgen receptors.
- Transforming to the hormone, estrogen that binds to one different kind of receptor on cells, known as estrogen receptor.
Effects on sperm count and sex drive
It is important to know that SARMs don’t affect sperm count or sex drive. But this is not the case with anabolic steroids. The manufacturers of SARMs wanted to create a supplement which could exert all the benefits of anabolic steroids without the negative side effects, like lessened sperm count or various other sex-related side effects. More and more people buy SARMs online because they have least negative effects on the users’ prostate like the prohormones or steroids have. In fact, there are some SARMs like LGD-2226 which helps in a proper sexual functioning besides helping in studies too.